Alpha - adrenoceptor antagonists and chemical 1 sympathetectomy exacerbate anaphylaxis - induced 2 hypotension , but not portal hypertension , in 3 anesthetized rats
نویسندگان
چکیده
Alpha-adrenoceptor antagonists and chemical 1 sympathetectomy exacerbate anaphylaxis-induced 2 hypotension, but not portal hypertension, in 3 anesthetized rats 4 5 Mofei Wang, Mamoru Tanida , Toshishige Shibamoto, and 6 Yasutaka Kurata 7 Department of Physiology II 1 , Kanazawa Medical University, Uchinada 8 920-0293, Japan. Department of Colorectal surgery 2 , The Fourth Affiliated 9 Hospital of China Medical University, Shenyang 110032, China. 10 11 Running head: Sympathetic nervous system and anaphylaxis 12 13 #, contributed equally 14 15 Correspondence to: Toshishige Shibamoto, M.D., Ph.D. 16 Professor and Chairman of Physiology 17 Department of Physiology II, 18 Kanazawa Medical University, 19 Uchinada 920-0293, Japan 20 Phone +81-76-286-2211 21 Fax +81-76-286-8010 22 E-mail [email protected] 23 24 The authors declare no relevant conflicts of interest, financial or otherwise. 25 26 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (August 15, 2013). doi:10.1152/ajpregu.00120.2013
منابع مشابه
Alpha-adrenoceptor antagonists and chemical sympathectomy exacerbate anaphylaxis-induced hypotension, but not portal hypertension, in anesthetized rats.
Anaphylactic shock is sometimes life-threatening, and it is accompanied by hepatic venoconstriction in animals, which, in part, accounts for anaphylactic hypotension. Roles of norepinephrine and α-adrenoceptor in anaphylaxis-induced hypotension and portal hypertension were investigated in anesthetized ovalbumin-sensitized Sprague-Dawley rats. The sensitized rats were randomly allocated to the f...
متن کاملHepatic venoconstriction is involved in anaphylactic hypotension in rats.
We determined the roles of liver and splanchnic vascular bed in anaphylactic hypotension in anesthetized rats and the effects of anaphylaxis on hepatic vascular resistances and liver weight in isolated perfused rat livers. In anesthetized rats sensitized with ovalbumin (1 mg), an intravenous injection of 0.6 mg ovalbumin caused not only a decrease in systemic arterial pressure from 120 +/- 9 to...
متن کاملInvolvement of splanchnic vascular bed in anaphylactic hypotension in anesthetized BALB/c mice.
Using in vivo and isolated perfused liver preparations of BALB/c mice, we determined the roles of the liver and splanchnic vascular bed in anaphylactic hypotension. Intravenous injection of ovalbumin antigen into intact-sensitized mice decreased systemic arterial pressure (P(sa)) from 92 +/- 2 to 39 +/- 3 (SE) mmHg but only slightly increased portal venous pressure (P(pv)) from 6.4 +/- 0.1 cmH(...
متن کاملThe Role of Lumbar Sympathetic Nerves in Regulation of Blood Flow to Skeletal Muscle during Anaphylactic Hypotension in Anesthetized Rats
During hypovolemic shock, skeletal muscle blood flow could be redistributed to vital organs via vasoconstriction in part evoked by activation of the innervating sympathetic nerve activity. However, it is not well known whether this mechanism operates during anaphylactic shock. We determined the femoral artery blood flow (FBF) and lumbar sympathetic nerve activity (LSNA) mainly regulating the hi...
متن کاملRat hepatic and splanchnic vascular responses to anaphylactic shock, compared with hemorrhagic or vasodilator-induced shock.
BACKGROUND Hemodynamics during anaphylactic shock remain unclear. We determined hepatic and splanchnic responses to anaphylactic hypotension, compared with hemorrhage or sodium nitroprusside (SNP)-induced hypotension, in anesthetized rats. MATERIALS AND METHODS Portal pressure, systemic arterial pressure (SAP), central venous pressure, portal and hepatic arterial blood flow were measured. Spl...
متن کامل